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L-arginine is considered to be generally safe. It might be effective at lowering blood pressure, reducing the symptoms of angina and PAD, and treating erectile dysfunction due to a physical cause.

However, if you take a blood pressure drug, talk to your doctor before using L-arginine.

Safety and side effects

Using L-arginine orally or topically is generally considered safe.

Oral use of L-arginine might cause:

L-arginine isn’t recommended for people who have had a recent heart attack due to concerns that the supplement might increase the risk of death.

L-arginine can worsen allergies or asthma. Use the supplement with caution if you have these conditions.

Be careful about taking L-arginine if you’ve had cold sores or genital herpes. Too much L-arginine in your system can potentially trigger the virus that causes those conditions.

Interactions

Possible interactions include:

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